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David Sinclair & Matthew LaPlante Intro (Part I)

2:15 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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AD: Levels

0:39 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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AD: InsideTracker

0:51 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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AD: Athletic Greens

1:00 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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David Sinclair & Matthew LaPlante Intro (Part II)

1:06 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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Unlike Supplements, Drugs Are Regulated Molecules

2:52 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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David Sinclair Doesn't Sell Supplements; He Wants to Remain Unbiased

1:09 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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Longevity Supplements & Molecules Target Survival Pathways: mTOR, AMPK, & Sirtuins

1:39 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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Essential for ATP Production & Sirtuin Activation, NAD Levels Decline With Age

1:58 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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Nicotinamide Riboside (250mg-1g/Day) Is a Safe & Effective NAD Booster

1:27 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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Mimicking Caloric Restriction, Nicotinamide Riboside Extends Lifespan in Yeast By 30%

1:19 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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NR Must Be Converted Into NMN Before Transforming Into NAD

0:36 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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In 700-Day Old Mice, NR Extends Lifespan By 9% & Increases Mitochondria Count

1:08 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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As an NR Precursor, Is Vitamin B3 a Viable Alternative for Boosting NAD?

1:17 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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In Human Studies, 250mg-1g/Day of NR Boosts NAD & Reduces Inflammation

2:04 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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In David Sinclair's Anti-Aging Studies, NMN > NR at the Same Dose

1:24 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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After Supplementing, SLC12 Transporters Help Cells Uptake NMN

1:04 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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In Mice, 400 mg/kg of NMN Increases Lifespan By 10-15% — Particularly in Females

2:25 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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David Sinclair Is Helping a Harvard Group Study NMN in Humans

1:02 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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In Humans, 250 mg/Day of NMN Improves Insulin-Stimulated Glucose Disposal

2:00 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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Effective for Treating Hangovers, IV NAD Drips Haven't Undergone Placebo Controlled Trials

2:30 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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NAD Is Too Large to Be Absorbed Into Cells; NMN & NR Are Smaller

0:53 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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Does Taking NR & NMN Sublingually Increase Bioavailability?

0:55 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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Despite Mice Studies Indicating Such, NAD Boosters Likely Don't Cause Cancer

1:54 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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David Sinclair Discovered Resveratrol Upregulates SIRT1 Activation 13-Fold

1:49 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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For Resveratrol Benefits, You'd Have to Drink 100+ Glasses of Red Wine Per Day

1:01 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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The Optimal Resveratrol Regimen: 250mg-1g/Day, Taken With a Fatty Solvent

1:26 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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In Mice, Resveratrol Protects Against the Western Diet's Negative Effects

1:01 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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Resveratrol Reduces Fasting Glucose, Increases Insulin Sensitivity, & Improves Cholesterol

1:33 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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The French Paradox: Is Red Wine the Recipe for Good Health?

0:42 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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Fisetin & Quercetin Kill Off Inflammatory Senescent Cells, Extending Lifespan in Mice

4:01 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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By Inhibiting mTOR & Mimicking Low Protein Intake, Rapamycin Extends Lifespan

2:00 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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By Stimulating Autophagy, Spermidine Extends Lifespan in Worms & Mice

2:17 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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As a Popular Type 2 Diabetes Drug, Metformin's Benefits Are Plentiful

4:18 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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The TAME Trial Is Examining Metformin's Anti-Aging Effectiveness

1:40 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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More Physicians Are Starting to Prescribe Metformin Off-Label

1:53 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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Metformin Only Reduces Muscle Size By ~5%

1:07 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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At 1-2g/Day, Berberine Is a Valid Metformin Alternative

2:16 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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David Sinclair's Protocol: 1g Resveratrol, 1g NNM, 1g Spermidine, 800mg Metformin, 0.5g Quercetin, 0.5g Fisetin

6:08 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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David & Matthew Outro

1:00 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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David Sinclair Outro

0:38 · NMN, NR, Resveratrol, Metformin & Other Longevity Molecules | Episode 4 - David Sinclairview episode

Lifespan with Dr. David Sinclair
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