and then here's what's interesting. I know I'm throwing a lot of stuff out there, but I just, you know, In leading up to chatting with you. I just started to dig into all these different off label uses of modafinil. So, apparently, the way that you described at modafinil Works earlier is almost the same way that cocaine Works in terms of its effect on dopamine.
Yeah, so there are some norepinephrine if there are definitely some parallels, but there are some important differences and one of the differences is that while modafinil appears to act pretty much exclusively by Locking that dopamine transporter. Cocaine has effects mediated by blockade of the dopamine transporter, just like modafinil but also serotonin Transporters to some extent and noradrenaline Transporters to some extent. Okay. So that's one thing that will discriminate, modafinil from cocaine. The other I think is has to do with what we call the pharmacokinetics. And this is you've already made reference to the pharmacokinetics, like, you know, its initial effect will be 40. Five to sixty minutes after Administration Peaks at two hours or, you know, remains for 16 point. So that's a very slow pharmacokinetic response that response that you get to modafinil cocaine. Cocaine is kind of an experiment of nature. So you can take coca leaves you can chew on them. Typically, people will do with it like a rock and this is what, you know, in the Andes.
Where did that a couple of times did you do? It was actually, you know, I I hear cocaine and I think, you know, addicted people. On going crazy, you know, vacuuming their living room for eight hours, but I tried a little bit of coca leaf. One of my friends gave me some is mixed with baking soda because apparently the baking soda, cannae causes a little bit of breaking of the captain, right in my lower lip, and and I just put a little bit of lower lip with baking soda and it felt like, I just had a little coffee kind of slowly right
system. So if you look at the pharmacokinetics of cocaine getting into the brain, when you take it in that matter, when you chew on a coca leaf, and it's slowly And through the gums and works its way through the bloodstream up to the brain. The pharmacokinetics are largely similar to those of modafinil. It's going to creep up slowly over a period of hours and it's going to drop over a period of hours. And as you just said, the cognitive experience is not dramatically different from modafinil. If you take cocaine and you inject it, do it take it orally. It's going to be the same one that you can actually get some through your stomach. And again, we slow rise and you'll just have sort of a general alertness improving and Thing effect, if you inject cocaine into your veins, that will get into the brain faster. Now, we're starting to get into the world. You have Euphoria, right? Or if you snort it, or if you smoke it, then it gets right into the brain. And that's when you see people, having these issues of, you know, or are experiencing the Euphoria, and then having the difficulties with dose escalation, and everything else that goes on with, with cocaine abuse. So when we published our data originally saying that this is a dopamine transporter, blocker. And here's our evidence. And here's why, and I believe those data have stood the test of time, but a lot of the reaction to that negative reaction to that concept was like, wait, cocaine blocks, the dopamine transporter. This is nothing like cocaine. Well, it's only the, when you have cocaine and a in a form that is chewing on the coca leaf or swallowing the coca leaf that has the similar pharmacokinetic profile. You have a similar experience and it's only when you change the pharmacokinetics and with modafinil A way to change the pharmacokinetics. You can't smoke it. You can't you can't really put it into a form that's injectable very effectively. So it is very different from cocaine in that respect. But they our concept has withstood. The test of time. It is binding to the dopamine transporter, the same site as cocaine
begs. The question about whether or not there's like an intranasal spray version of modafinil just because I know a lot of people now are like doing Enter nasal NAD, intranasal city,
right? Oxytocin. Yeah, I don't know if it'd work. I yet. No, I think I would say this probably it's been tried and if somebody's mad right by now, the news would be out. That's my guess. Yeah, it's a very funny compound in terms of its physical properties and very difficult to work with and so interest. There's yeah, as far as I know, there's no way to get the as direct shot to the
How Modafinil & Cocaine's Neurotransmitter & Pharmacokinetic Effects Differ
Modafinil: Is This Wildly Popular Smart Drug Safe And Effective? (& What It Can Do For Your Sleep Cycles & Brain Health). - Jonathan Wisor