want to unpack something related to something, you kind of alluded to earlier. ER, now be different people responding in different ways. And when I was thinking about this and I began to think about it the same way as one would think about coffee. All right, we know for example and many people are aware if they'd taken a 23andMe test, you know, they're reported to be a fast coffee oxidizer versus a slow coffee oxidizer. Based on these. These cyp genes and these would be related to liver enzymes responsible for breaking down certain compounds. We know that that modafinil is processed in the liver and some people have a higher activity. Buddy of those genes and some people a lower activity.
Yeah. These are the cytochrome side. Yeah, exactly.
Cytochrome p450. Yeah. Yeah. So there's one of all the modafinil cytochrome P to c19 is the name of it and apparently people who would have a higher activity of those enzymes would break down modafinil more quickly and potentially feel it less than the people with lower activity of those enzymes. And so that that's where I suspect. Perhaps the the The difference in the way that certain people would feel when taking modafinil would lie. And so, then I got to thinking, well, okay, so we know that in people who are for example, a fast coffee oxidizer. There are certain things that can slow down the activity of those, those cyp enzymes that are their cyp Inhibitors. And that would actually allow you to if you're breaking it down too quickly for it to remain in your bloodstream for a longer period of time. Timer for you, feel it more. And so, I looked up all these cyp Inhibitors and grapefruits. The most common great. First one. You gotta be really careful. Right? Right. Because if you take that same time as a pharmaceutical, you can actually inhibit. The breakdown of that pharmaceutical do certain extent, but bacopa, a common. Something else that's kind of used as a smart drug for memory. That's another one that seemed to inhibit it. Bear Berean was another and then there's a California, poppy and chaste tree. So it turns out that there are certain things. Things that if you weren't really feeling the modafinil or you felt like you are non-responder, you could take one of these cyp Inhibitors at the same time and kind of assess whether or not that might be the case, you know, so it seems there's almost like this metabolic tolerance to it. And then also kind of this dopamine tolerance to it. That could be hit in two different ways.
Right? I think that's true. I would just offer a significant level of caution to somebody who wants to mess with their liver enzymes. Exactly.
CYP Inhibitors Like Grapefruit, Bacopa, & Berberine May Boost Modafinil's Effects
Modafinil: Is This Wildly Popular Smart Drug Safe And Effective? (& What It Can Do For Your Sleep Cycles & Brain Health). - Jonathan Wisor