but

let's talk about another form

of magnesium called magnesium 308 magnesium

3 and 8 is a form of magnesium that has garnered a lot of attention

because of its potential impact on brain function. So

generally only a small

portion of the Magnesium ingested in a supplement form reaches the brain and this is due to the intricate active transport symptom systems that control the progression of magnesium from the digestive tract into the bloodstream and then subsequently from the bloodstream across the blood-brain barrier the

body establishes and manages a very tight concentration gradient. It creates a higher magnesium

level in the blood compared to the cerebral spinal fluid and

that allows a very

controlled Quantity of magnesium that can actually get transported into the brain.

This precise regulation is really important to maintaining

this equilibrium of magnesium necessary for optimal brain function. So in humans,

it's been found that even an increase up to 300% in blood magnesium results in less than 19

percent change in the cerebral spinal fluid magnesium content and

I think this really highlights the significant role that

physiological processes and maintaining magnesium balanced play. Say which then influence the brain health and function. So

some animal evidence suggests that magnesium three and eight can easily get across the blood-brain

barrier and

at a human equivalent dose of 8.1

milligrams per kilogram body weight. So that would be around six hundred and sixty two milligrams for 180 pound person can improve cognition and decreased amyloid-beta plaques. Now, this is in the brains of mice and

it's thought that the Magnesium three and a is uniquely effective

in crossing the blood-brain barrier. Year due to its specific molecular structure. So this form

of magnesium is chelated to the ironic acid and that is a metabolite of vitamin C. So this chelation enhances

its ability to pass through the blood-brain barrier or so. It's thought the precise

mechanism by which magnesium 3 and 8

bypasses this tightly regulated concentration gradient between the blood and the brain is not fully understood. It

is believe though that its molecular structure. Sure, does somehow facilitate

easier entry into the brain, thereby increasing concentration of magnesium in the brain more effectively than other forms of magnesium. That is solely based on a very small and limited number of animal studies when we turn to human studies only a couple have explored the effects of magnesium 3 and 8. So these

studies are I want to point out industry-funded

which does invite us to consider a potential conflict of interest. So

the initial That I think garnered a lot of attention was published in 2016. It was a small scale study that only had 40 for participants

total those in the treatment group took daily doses of about 1,500 to 2,000 milligrams of magnesium 3 and 8. So this is Mark marketed as mag teen and they took

it for over 12

weeks based. So this was based on their body weight. That's why there's a range in DOS

the findings of this study. I We think are underwhelming. So the treatment

group only achieved a marginal increase in plasma magnesium levels with no elevation noted in red blood cell magnesium levels compared to the placebo group. Additionally.

There was a significant increase in urinary magnesium which suggests

that most of the supplemented Magnesium 3 and 8 was actually being excreted through urine. There

is some cognitive tests that were also done. There was no significant

difference observed when each of these four different, Your cognitive tests were looked at in isolation compared to the placebo group. But

if the data was all pulled together, so all for

cognitive tests were then pull together. Then there was a suggested mystically significant difference in cognitive function compared to the placebo group, obviously

the suggest a degree of statistical uncertainty in the studies

conclusions, whether or not it was just due to a small sample size. I said, there's only 44 people in the study. If there were four hundred and forty-four people there would have been more of a stronger signal and the data wouldn't have had to have been pulled together or maybe there really isn't much of an effect. There's no telling

the second study was also industry-funded

which I think is important to keep in mind. This study was published in 2022 and

it involved 100 participants and

the treatment group was given 400 mg of magnesium three and a along Vitamins C DB 6 and phosphatidyl serine in contrast the placebo group received only 2 grams of a starch capsule.

So despite the absence of any elevation

of serum or brain magnesium levels. The treatment group did have improved cognitive test performance compared to the placebo group.

I would say this study raises pretty significant questions

around causations because the treatment group was not just given magnesium three and eight they were given a variety of Ottomans, they were given by ottoman see by the B vitamins vitamin D be

6, but they were also given phosphatidyl

serine. So

I think to a be able to establish a solid conclusion

that magnesium 3 and 8 is responsible for improving cognitive function. The

placebo group should have gotten all those other vitamins and the phosphatidyl

serine but not the Magnesium 3 & 8. However

that was not the way the study was done. So in my

opinion, I think it's an interesting study but really no conclusions can be stated directly. About magnesium three and eight itself.