norepinephrine and we've got histamine and then there's also this interesting molecule called orexin. Have you looked into how that ties into modafinil?
Yeah, Rex in is sort of an upstream regulator of all of these neurotransmitters that we've talked about. And so it the orexin producing cells will feed into and potentially activate. All of these different cells types that we've mentioned. So modafinil is Downstream from that and in people who have narcolepsy, they are lacking the orexin That would otherwise be there. It was basically like the Wake Drive sick, right? That's right. Yeah,
it says you you'd see a drop in orexin as nighttime approaches Rand and then an increase in adenosine, which, which coffee or caffeine would would decrease the stimulation of or at least, it would fill those receptors that identity would normally interact with so Rex and would almost become like the opposite of adenosine in a sense. Right? Comes awake
Drive. Yeah, so Rex. And yeah, it's it's kind of a master orchestrator of the wake. Promoting Drive in the hypothalamus. One of the most basic functional areas of the brain and it in turn will project to and activate these other the dopamine-producing cells, the histamine producing cells. But so in narcolepsy for instance where they lack or Exon, you need this pharmaceutical way of boosting, those Downstream signals and modafinil works very effectively in that context. Okay. Got it.
Modafinil Boosts Orexin, a Wakefulness-Promoting Molecule in the Hypothalamus
Modafinil: Is This Wildly Popular Smart Drug Safe And Effective? (& What It Can Do For Your Sleep Cycles & Brain Health). - Jonathan Wisor