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David Sinclair Intro

1:27 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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Without Intervention, Alzheimer's Disease Rates May Double By 2060

3:02 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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AD: Athletic Greens

1:06 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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AD: InsideTracker

1:05 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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AD: Levels

0:53 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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Aging Is Largely the Result of Cellular Ex-Differentiation

1:43 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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The Brain Ages Significantly Slower Than the Rest of the Body

3:09 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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The Average Lifespan > The Average Age of Dementia Onset

1:45 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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Humans Used to Live Until Their 40s; Now Grandmas Use iPhones

3:26 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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The Three Longevity Pathways Work Together: mTOR, AMPK, & Sirtuins

1:34 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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While Fasting, mTOR Activates Autophagy — The Recycling of Misfolded Proteins

0:59 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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Upregulating SIRT1 in the Nerve Cells of Mice Slows Brain Aging

3:08 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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A Mediterranean Diet Reduces Dementia Risk & Protects Against Brain Aging

1:24 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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Mediterranean Diets Are High in Resveratrol, Olive Oil, & Xenohormetic Molecules

1:24 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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Unlike Carnivore & Western Diets, Mediterranean & Okinawan Diets Mimic Adversity

0:57 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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B Vitamin Deficiencies Accelerate Aging, Increasing Dementia & Heart Disease Risk

1:19 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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Elevated Homocysteine (>10 mcmol/L) Indicates Poor Cardiovascular Health

1:18 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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High Homocysteine Levels Increase Dementia Susceptibility

2:45 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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Consume >1g of EPA Daily; Omega-3 Fatty Acids Improve Memory & Counteract Depression

2:29 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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Omega-3s Improve Nerve Cell Membrane Health in the Brain

0:44 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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Aerobic Exercise Improves Executive Function in Sedentary Adults

2:31 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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10 Weeks of Strength Training Increases BDNF in Elderly Individuals

0:54 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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Metformin Improves Cognitive Abilities & Memory in Fish

4:34 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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Metformin Improves Executive Function in Non-Diabetics With Dementia

1:00 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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Metformin Appears to Reduce Dementia Risk By 55%

0:33 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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David Sinclair Is Studying How Metformin Impacts NAD Levels

0:40 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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Brain NAD Declines With Age; NAD Boosters Can Restore Levels

1:01 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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In a 2004 Study, NADH Slowed Alzheimer's Disease Progression

1:22 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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A Combination of NR & Pterostilbene Slows the Progression of ALS

2:06 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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NMN Facilitates Brain Blood Vessel Formation in Mice, Improving Cognition

1:31 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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Elevating Brain SIRT1 Levels in Mice Protects Against Disease & Improves Memory

1:08 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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SIRT1 & NAD Control the Sleep-Wake Cycle; Deficiencies Impair Sleep

1:29 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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David Sinclair's Sleep Tips: NMN, Magnesium, L-Theanine, & Light Exposure

1:13 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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Sleep Deprivation Dangers: Elevated Amyloid-Beta & Increased Death Risk

2:05 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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You Have a Responsibility to Your Family to Maintain Brain Health

0:47 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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Anti-Aging Advances of the Future Are Coming Sooner Than Expected

2:30 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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David Sinclair Outro

0:49 · The Science of Keeping the Brain Healthy | Episode 7 - David Sinclairview episode

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