mention, which I'm actually interested in, and that would be this idea that if you are consistently flooding, The receptors with dopamine, could you create a state of? I guess what? I might call dopamine in sensitivity, in which things that would Normally a list of the dopamine response become less enjoyable or require more of them to become as enjoyable. Like could you theoretically or have you seen in the literature? For example, increased susceptibility to overeating because food isn't as rewarding or you know, I would theorize perhaps even appetite Cravings or more snacking because you're looking for more dopamine. Hits during the day, you know, maybe (expletive) might become less enjoyable, you know any of these things. Rely upon dopamine if you need more and more dopamine. And then this is just a theory. I haven't seen literature on this. It would seem that that constantly flooding The receptors of dopamine like that might induce some kind of dopamine insensitivity. Your tolerance to dopamine itself. Yeah,
I guess I'm not aware of anything like that happening with modafinil. That's a, that's a good question for for you to pursue and that's probably something that will look up myself. Later. I'm not aware of anything like that happening with modafinil, certainly that kind of mechanism exists in the in nervous system. There's no doubt that it does, it sound like that's often. If someone takes methamphetamine, which methamphetamine boosts dopamine or dopamine production, through somewhat different ways than modafinil. We have to discriminate them. They both while they both act on dopamine. It's by quite distinct mechanisms, but like with methamphetamine users, they will often undergo dose escalation and it's probably because of what you're describing here. Like you're sort of desensitizing the system. You need to crank it more and more to have a positive affect.
Does Long-Term Modafinil Use Cause Dopamine Insensitivity?
Modafinil: Is This Wildly Popular Smart Drug Safe And Effective? (& What It Can Do For Your Sleep Cycles & Brain Health). - Jonathan Wisor