Similarly, from what I understand is also affected by modafinil. And and perhaps it's not just dopamine that's being acted upon in terms of actually, you know, I guess only flooding cells with dopamine or decreasing actual reuptake of dopamine, but then is norepinephrine also affected
in some way. So, I would say sort of yes and no. Yes, it is clear that if you measure norepinephrine in the brains of, this would be an experimental animals. People have done this, if you measure changes in norepinephrine, when an animal is given modafinil, you do see an increase in norepinephrine as well. Now, it's probably indirect and one of the things that we know about neurotransmitters is that they're all talking with each other simultaneously. It's just this cocktail of chemicals in the brain. And so if you block the reuptake of dopamine by the mechanism that I just described, right? You're going those dopaminergic cells, some of the other cells that That they will activate contact and activate, will be cells. That are producing norepinephrine. Right? And so then those norepinephrine cells are at, okay, we need to be recruited into this process to, right? And so then we have an increase in norepinephrine release in, right? So, yeah, so that's going to help. Also focus our attention, right? Focus
our attention or an excess cause some of the, you know, potential anxiety, that. I know some people have reported, you know, when using modafinil, especially in higher dosages. Because, you know, do, I mean, I wouldn't say at least in my own personal experience, even just using a like a dopamine precursor, like, mucuna. For example, it doesn't seem to produce any, any really pronounced anxiety, affects. It's more like a feel-good, wakefulness, type of effect. But then, I think norepinephrine, it does kind of give you like this anxious, kind of jittery effect that.
Yeah, that, that makes sense. I think that's one of the things that norepinephrine can do. It's, you know, it's a central mediator of the cell. Called fight or flight response, the sympathetic response. And so yeah. Anything that does Boost norepinephrine could have that effect on. Probably, you know, certainly that's not the case in every one who takes modafinil. And it probably has to do with individual variability in sort of neurochemistry.
I want to get out tightly
the dopamine, links to the norepinephrine in that particular, individuals, central nervous system.
By Blocking Dopamine Reuptake, Modafinil Indirectly Stimulates Norepinephrine Release
Modafinil: Is This Wildly Popular Smart Drug Safe And Effective? (& What It Can Do For Your Sleep Cycles & Brain Health). - Jonathan Wisor