our next story. We look at how emulsifiers are the most widely used food. Additives. What are they doing to our gut microbiome
today? When grocery shopping, unless you're sticking to the produce aisle. It's nearly impossible to To avoid processed foods. Particularly if eating the standard American diet, characterized not only by insufficient plant foods and too much meat, Dairy and eggs, but also Lotsa processed junk and along with that and increase exposure to food, additives, for example, the artificial sweetener, sucralose old the Splenda can disrupt the human gut microbiome and induce glucose intolerance. In other words. It can make your blood sugar's worse. Instead of better. It's relatively easy to avoid artificial. But it may be more difficult to avoid ingestion of emulsifiers because they're commonly added to. So many foods. In fact, most of ours are the most widely used food additives and most processed foods contain one or more of them. We Now consume a most fires by the Megaton every year. Thanks to a multi billion dollar industry. You can only find a most fires in (expletive) dressings, fatty spreads baked goods, mayonnaise salad, dressings, candy and beverages. Why do we care? Like all authorized food, additives. Most of ours have been evaluated by risk assessors, who consider them as safe. However, there are growing concerns among scientists about their potentially harmful effects on our intestinal barrier, in terms of causing a leaky gut as well as their effects on our microbiome. Moreover, they could possibly increase the absorption of environmental toxins present in the food. We know that the consumption of ultra-processed foods may be a contributor to weight gain. For example, healthier. Girl live population. Don't just have low meat intake and high plant intake but they're eating minimally processed foods. May be the emulsifiers found in processed foods could be playing a role based on a number of preclinical studies. But who cares, if emulsifiers make rats, gain weight, when you read it emulsifiers can cause striking changes in the microbiota. They're not talking about within human beings. Mice, are often used to study diets impact on the microbiome. But we only share a few percent of bacterial genes in common, even the gut Flora of different Mouse. Strains can be considerably different from each other. So they can't even extrapolate from one type of mouse to another. How are you supposed to translate results from mice to human beings remarkably. There's been little studied the potential harmful effects of ingested, emulsifiers in us, for example, lecithin, perhaps best known as a key. Component of egg yolks was found to be worse than Bait 80 in terms of allowing bacteria to leak through the gut, wall, into the bloodstream. But whether lecithin consumption in humans causes the same problem is yet to be determined. There's certainly a paucity of human trials on the effects of emulsifiers and processed foods, but we at least have data on human tissue cells and gut, Flora dietary emulsifiers directly, altered the composition of the human microbiome, ex Vivo potentiating, intestinal inflammation, ex Vivo. Mo means outside the body. Researchers inoculated an artificial gut with fresh, human feces into that a nice stable culture going and then added carboxymethyl cellulose or polysorbate. 80 and got a boost in pro-inflammatory potential starting with in one day with the carboxymethyl, cellulose, and within the first week with polysorbate, 80 this approach revealed that both emulsifiers acted directly upon human gut bugs to increase their pro-inflammatory. If you didn't test the effect of these emulsifiers on the protective mucus layer, and petri dish cultures of human gut lining cells, you'll find that they can partially disrupt the protecting layer, but both this study in the last used, emulsifier concentrations that were far in excess of what people might typically get day-to-day. This is probably the study that raised the greatest potential concern. The researchers surgically obtained, not just cells, but actual intestinal wall tissue. And found that polysorbate 80 could double the invasion of E coli through the intestinal lining tissue. Whereas adding fiber, in this case, fiber from plantains could seal up the gut wall tissue twice as tight
Emulsifiers in Processed Foods Are Detrimental to the Microbiome
Nutrition Facts Grab Bag 21 - Michael Greger, M.D.