and then, in addition to that and I do want to get into and I think we will All kind of variations in response to modafinil. I've some of my own hypotheses regarding that but then also have you looked into histamine at all and a histamine, allergic response to modafinil. So
yes, there is definitely a histamine Urgent Response as well. And again, you know, we have to emphasize that all of these neurotransmitters talk to talk with each other, you know, and so For Better or Worse, you're going to when you try as selectively as you might try to Activate one, you're messing with the whole system and in some way or another, which may ultimately be therapeutic for you or it may not be. But yes, histamine is another one that is the histamine producing cells. And so histamine is another type of cell that's associated with arousal. This is associated with cognitive enhancement. Right? And so, and the way to think about that is if you take an antihistamine, an allergy drug, you're going to be potentially in a fog, right?
My son, I wasn't happy about this. Is that grandma's house. And, and he last week and he had a, an allergic reaction to pollen. He gets little bit of seasonal allergy and she gave him Benadryl and he has ever rarely, you know, we're pretty natural at our house. He's rarely ever, you know, ingested, a pharmaceutical, you know, he was sleepy and his eyes are rolling over. He's a dad was going on. And said, well, she had shutting down one of the excitatory compounds in your body histamine and you're probably going to, you know, sleep pretty solid tonight. You probably have some bizarre dreams, but, but yeah, but histamine and Excess or something. That would block. Histamine seems to really printout produce those. This this kind of wakefulness effect.
Well, so let's be clear that that's what you just described. Is it at the effective and antihistamines or something right blocks to his mean? Yeah, right. So modafinil again indirectly. We think is the opposite of that. So answer put it is again sending out a signal to the cells to produce the histamine that says, hey it's time for you, histamine cells to be more active and release more histamine and the histamine. Again, as opposed to an antihistamine, the histamine itself is in general associated with improved cognition cognitive enhancement. Yeah. So this may be another aspect of the modafinil story. They are so critical for its it's a cognitive enhancement properties.
I saw one study that showed about a hundred fifty percent increase in histamine release sounds
about right once we got out right dopamine
By Stimulating Histamine Release, Modafinil Improves Cognition
Modafinil: Is This Wildly Popular Smart Drug Safe And Effective? (& What It Can Do For Your Sleep Cycles & Brain Health). - Jonathan Wisor