it is interesting when you say that about Parkinson's because there's another very common compound that's being used, increasingly again amongst like the smart drug and the bio hacking community. And that is nicotine, which suppresses kind of the gabaergic activity on on dopaminergic neurons meaning, it would, it would keep inhibitory neurotransmitters from from essentially shutting down some of the response to dopamine, which Gina was an issue in Parkinson's and seems doing increase the acetylcholine activity. And so, actually, a lot of people are, are combining like a milligram of nicotine with what would be considered like a microdose. I'm going to have to know like 15 grams of modafinil, and that's kind of, like a stack that's being used because you're getting a little bit of a dopaminergic protective effect with the nicotine, and then a further dopamine release with the modafinil. And, you know, the other the other stack that people often use This is just caffeine because, you know, and I think the reasoning is basically, you know that adenosine I talked about earlier. So you've got three different mechanisms of action. Really, you've got the decrease in the gabaergic, stimulation of those dopaminergic, receptors with nicotine. You have the increase in dopamine norepinephrine, histamine, and orexin from the modafinil. And then you've got the blockage of the adenosine receptors from the caffeine. And so you'll see people stacking caffeine nicotine and modafinil to kind of hit cognition and awareness on three different levels. So it's interesting. What people are cooking up in their kitchens these days.
Many Biohackers Stack Modafinil, Nicotine, & Caffeine
Modafinil: Is This Wildly Popular Smart Drug Safe And Effective? (& What It Can Do For Your Sleep Cycles & Brain Health). - Jonathan Wisor