And then there's the third type. Which is the Adaptive immune system, and you'll notice that leading up until now, I haven't said the word antibody at all. And that's because it is the job not of the skin, or the mucous, or the microbiome, or the innate immune system to produce antibodies that can recognize specific Invaders. But rather it is the job of the Adaptive immune system to create antibodies against bacteria, viruses, and even parasites, and even physical. Intruders to your system, so the Adaptive immune system has this incredible ability to show up at the site of invasion or infection or inflammation. It's called there by various various cues, including the cytokines that we talked about earlier and what it does. Is it actually Attaches to, and creates a sort of a, an imprint of the shape of whatever Invader happens to be there. So, if that particular in invading bacteria or virus has a contour, that's kind of rippled or kind of spiky, or whatever shape. It happens to have, it creates an imprint of that. And then using that imprint in concert with some other cells creates antibodies that are specific to recognize that invader. The body ever have that Invader inside of it. Again. Now, that's why it's called the Adaptive immune system. And in many ways, it creates a memory of a prior infection, so that these antibodies can be made any time. That same Invader comes back again. Alright, and so, this is the basis of what we call immunity. This is the basis of what we call in an enhanced ability to combat certain types of infections, and its really a wonderful. And I mean, just, I can't even And state, how incredible this really is, that all of our bodies have this capacity, right? We have something called leukocytes. These are essentially white blood cells. We have red blood cells and white blood cells. And they both are derived from the same type of origin cell. It's a stem cell when you hear stem cells, stem cell just means a cell that can become many different types of other cells. We sometimes hear about stem cells in terms of people that are getting injections of, Cells or the potential therapeutic effects of or potential of stem cells, but we all Harbor certain stem cells within us as well. That can become lots of different cell types and there's one particular type of stem cell which is the hemopoietic stem cell, which can give rise to red, blood cells and white blood cells. And in general, these reside in the marrow at least in adults. So in our bone marrow, we have this ability to make certain cells that can go out when they are called out. Lee, they called out to sites of infection and create antibodies, and then maintain those antibodies in our system, or have a memory of that particular infection. So that if the infection comes back again, we can kill it off immediately and it doesn't have to pass through these multiple stages of first the innate response, then the Adaptive response taking some time. Now, there are a lot more details to the Adaptive immune system, but I just want to emphasize a few points that might be relevant. First of all, the Name of the antibodies that are created sometimes come in the form of IGM and IGG, things of that sort. This isn't a full Deep dive Immunology class, but I G stands for immunoglobulin. Okay. So the immunoglobulins are part of the Adaptive immune response and in creating antibodies, if you hear IGM, the IGM is the first of the Adaptive immune responses. Has and it tends to come on earlier. So if somebody is immuno positive for IGM, for a particular type of viral or bacterial Invader, that means that it was a fairly recent infection later. One creates the Adaptive immune system. I should say, creates an IGG, which is the more stable form of the specific antibody, that's going to recognize a given Invader. So IGG tends to come up a little bit later. So, just to recap something gets into your system, through your eyes through. Bill some hole in your skin, your skin, a cut through your mouth sexually. Transmitted diseases come in through the mucous, membranes that are on the genitalia or in the genitalia. Sexually transmitted disease airborne disease gets into the mucus, somehow gets into the bloodstream. Then there's the innate response which is a more General response of trying to contain and combat the infection or Invader. And then the Adaptive response is the one that It generates the antibodies first, the IGM response the immunoglobulin, M response and then the immunoglobulin G response, IGG response.