We want to activate AMPK. So, how do you do that? You actually eat less, you fast, and that'll turn on AMPK. It'll do a few things. It'll make your body more sensitive to insulin, suck the sugar out of your bloodstream, which can be toxic if it stays high. It also ramps up the energy-producing centers of the body, these membrane-filled bags, which are actually ancient bacteria living in our bodies called mitochondria.