Dr. Matthew Hill: How Cannabis Impacts Health & the Potential Risks

There's never been an account of someone actually dying from a cannabis overdose or a THC overdose. I mean, certainly people can do stupid things while they're intoxicated that result in their death, but in the same manner that someone can die from consuming too much opiates, that doesn't seem to be physically possible with cannabinoids as far as we've seen so far.

A lot of what the munchies is is this ability to kind of almost lock in the reward value of food so that it doesn't decay, despite satiety, despite eating over time. It just keeps it highly salient so that they want to work for it still. And then, similarly, we've... also done work to show it can block satiety signals.

The amount of THC that is within the cannabis plant will influence the, you know, how high a person's going to get when they consume it.

I think that's this very bizarre and interesting component of cannabinoid signaling is why the brain would have evolved in a way to allow every other neurotransmitter system to be actively and directly regulated by endocannabinoids, but dopamine has kind of spared from this.