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In the mouse, in 2008, we published that just upregulating the SIRT1 gene in the nerve cells of a mouse's brain was sufficient to slow aging and prevent those loops and bundles from changing. And that was the first evidence you could even slow down a mouse's brain
age.
David Sinclair
Upregulating SIRT1 in the Nerve Cells of Mice Slows Brain Aging
The Science of Keeping the Brain Healthy | Episode 7
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