Episode 102: Adam Konopka talks about metformin’s effects on healthspan and lifespan
STEM-TalkGo to Podcast Page

Episode 102: Adam Konopka talks about metformin’s effects on healthspan and lifespan

STEM-TalkGo to Podcast Page

STEM-Talk
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44 Clips
·
Jan 28, 2020
Top Moments
One of the best predictors of mortality is cardiorespiratory fitness.
0:05
To Extend Your Healthspan, Exercise to Improve Cardiorespiratory Fitness
Aging is the greatest risk factor for nearly every chronic disease and morbidity that people face.
0:04
Adam is Studying the Effectiveness of Rapamycin & Metformin in Delaying Osteoarthritis
Metformin mitigates the exercise-induced improvements in insulin sensitivity and cardiorespiratory fitness through its inhibition of skeletal muscle mitochondrial adaptations.
0:13
Adam Expands on His Finding: Metformin Blunts the Beneficial Effects of Exercise
No matter what, exercise is important ... Exercise is a valuable and effective strategy to improve our health.
0:10
Metformin Blunts Exercise's Beneficial Effect on Insulin Sensitivity
Clips
1

STEM-Talk Intro
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2

Dawn & Ken Intro
0:20
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3

Dawn Introduces Dr. Adam Konopka
0:42
exercise
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4

Ken Reads This Episode's Winning STEM-Talk Review
2:27
podcastscience
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5

Ken Introduces Dr. Adam Konopka
0:05
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6

STEM-Talk Intro
0:04
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7

Dawn Introduces Her Co-Host, Ken Ford, and Dr. Adam Konopka
0:12
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Why Adam Decided to Establish His Lab at the University of Illinois
0:28
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9

How Adam Became Interested in Competitive Swimming
0:45
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Adam's Interest in Competitive Swimming Led Him to Major in Exercise Science
0:36
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Adam Minored in Entrepreneurship Because He Wanted to Start His Own Business
0:29
businessentrepreneurship
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Adam's First Research Experience Was Focused on the Health Benefits of Exercise
0:42
exercise
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Adam Once Studied Muscle Mass Loss in Astronauts
1:06
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Elevated Mitochondrial Reactive Oxygen Species Production May Reduce Insulin Sensitivity
0:51
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Exercise Reduces Mitochondrial Defects Associated with Obesity and Insulin Resistance
1:36
exerciseobesity
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16

Adam's Research Aims to Translate Cell Culture Findings to Improve Human Health
1:15
glucose
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Metformin Doesn't Inhibit Glucagon-Stimulated Glucose Production
1:08
glucose
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While at CSU, Adam Studied the Joint Effect of Metformin and Exercise on Metabolic Health
0:33
exercise
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Adam is Studying the Effectiveness of Rapamycin & Metformin in Delaying Osteoarthritis
2:52
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20

Adam is Studying How Rapamycin Inhibits mTOR in Muscle
0:36
muscle
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Adam Has Been Studying the Interaction of Exercise & Metformin Since His Post-Doc
0:28
exercise
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Adam Expands on His Finding: Metformin Blunts the Beneficial Effects of Exercise
1:54
exercise
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23

Metformin Blunts Exercise's Beneficial Effect on Insulin Sensitivity
1:06
exercise
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The More Metabolically Unhealthy, the Greater Potential Benefits from Exercise & Metformin
2:41
exercise
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Adam Plans to Study Metformin's Effects on a Range of Metabolically Healthy Individuals
1:45
exercise
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STEM-Talk Interlude
0:22
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Is it Possible to Pulse Metformin Intake to Limit its Adverse Effects on Exercise?
1:42
exercise
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The Higher Your Type 2 Diabetes Risk, the Less Metformin Inhibits Exercise's Beneficial Effects
1:36
exercise
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Metformin Inhibits Exercise-Induced Improvements in Mitochondrial Respiration
2:08
exercise
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The TAME Trial Isn't Designed to Determine Whether Metformin Extends Healthspan
2:11
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Ken Wishes the TAME Trial Utilzied Rapamycin Instead of Metformin
0:43
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Adam Believes a Metformin Trial in Healthy Individuals is Warranted
0:55
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Metformin May Only Extend Healthspan in Individuals at Risk for Type 2 Diabetes
1:38
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How Would Adam Design a Healthspan-Extending Intervention Trial?
3:10
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If Adam Were to Study Metformin's Effect on Healthspan, How Would He Adjust for Diet & Lifestyle Variables?
1:16
exercise
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Will Pharmacological Methods Prove More Effective at Extending Healthspan & Lifespan Than Exercise?
1:55
exercise
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PPAR-D Agonists Are a Class of Drugs That Mimic Exercise's Pharmacological Effects
1:11
exercise
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To Extend Your Healthspan, Exercise to Improve Cardiorespiratory Fitness
1:06
exercise
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Adam's Exercise Routine Includes Lots of Endurance Running & Biking
0:38
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How Endurance Training Changed Adam's Fast-Twitch/Slow-Twitch Muscle Profile
0:35
muscle
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Even with a Young Child, Adam & His Wife Exercise in Their Spare Time
0:44
childrunning
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Adam, Ken, & Dawn Outro
0:09
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Dawn & Ken Outro
0:56
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44

Rate & Review STEM-Talk
0:28
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Topic: 48i

STEM-Talk Intro

Episode 102: Adam Konopka talks about metformin’s effects on healthspan and lifespan
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Episode 102: Adam Konopka talks about metformin’s effects on healthspan and lifespan
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