Special episode: Peter answers questions on longevity, supplements, protein, fasting, apoB, statins, and more

If you were on a really low carbohydrate/really low saturated fat diet, you would indeed lower your ApoB. Would you lower it to the levels that I think are necessary to make ASCVD irrelevant? Most people, probably not. And then would that be a diet that for most people is sustainable long-term? That's probably a very individual decision.

My target for ApoB is 30-40 mg/dL. Therefore, that would require pharmacology. And so I take 3 drugs to do that. I take a PCSK9 inhibitor called Repatha, and I take a combo drug called Nexlizet, which is bempedoic acid and ezetimibe combined into a single pill.

I use Carlson's EPA and DHA ... It is the highest EPA version that they have. So by taking 4 of these capsules a day, I'm taking roughly 2 grams of EPA a day and probably a gram and a half of DHA.

I take ashwagandha. I take 600 mg of ashwagandha. I recently switched to the Solgar brand. I take 2 g of glycine. I use the Throne brand. I take magnesium l-threonate, which I just mentioned. I use the Magtein brand.

A year ago, I was not taking the Pendulum probiotic ... I think this is the most rigorously tested and validated probiotic out there. And in a small but double-blinded randomized clinical trial, it demonstrated a .6%—meaning .6 absolute percentage point—reduction in hemoglobin A1c in people with type 2 diabetes.

It's better to have a 7 out of 10 diet in terms of quality and perfection that you can sustain indefinitely than a 10/10 diet that you can only sustain for 3 or 6 months.

I really do spend a lot of time looking at [anti-aging] technology. I haven't seen many examples where there's a bigger mismatch between what is actually happening scientifically and what is being talked about in the press, on social media, on podcasts—and that chasm is enormous.

I had no way of knowing if my fasting protocol of 7-10 days of water-only once a quarter or 3 days once a month— Was that too much? Was that too little? Was that doing anything? No idea. To this day, I have no idea if that provided any benefit at all. I could certainly point to some negative things it did...

I take Slowmag ... I take 2 or 3 of those every day. So, that is a slowly and completely absorbed form of magnesium. All in all, I'm trying to get up to about a gram of total magnesium or elemental magnesium in my system a day. And I get that through Slowmag, through magnesium l-threonate, and through magnesium oxide.

If I had some biomarker that could convince me that a 7-day fast, even once a year, had a meaningful rewrite on some negative processes in my body, I would happily make that sacrifice again; but in the absence of knowing that, the cost is a bit high right now.

I don't find the data for people below 50 having an increase in mortality with high protein being at all convincing. I think that is easily attributed to caloric excess as opposed to protein excess.

There are things about us as we age that we have the capacity to reduce the rate of change on—we can slow them down—but I've seen no real evidence that we can reverse them in a meaningful way.

Biological terrorism would be the single greatest threat to our species, simply based on the low barriers to entry and the ease with which there's proliferation.

I take 5000 IU of vitamin D. Why? Largely because this is one of those things where I think the risk is insanely low. I think this is really a tricycle, and I'm not sure what I'm picking up— I think it's more than a penny. I definitely think it's less than a gold coin. It might be a five-dollar bill.

I used to take 50 mg of B6 daily. I've now lowered that to 3 times a week. We have seen some people who, when they take too much B6, can actually develop a sort of neuropathy as a result of it.

There's no doubt there are benefits of a baby aspirin, but they're outweighed by the bleeding risks that are associated with aspirin. In particular, if you fall and hit your head, that becomes a bigger liability.

The efficacy curves show that statins hit their maximum efficacy at about a quarter dose.