Having Grown Up in Australia, David Was Devastated By the Wildfires

Dr. David Sinclair Intro (Episode Preview)

0:58 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

The Rich Roll Podcast Intro

0:18 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

Rich Introduces Dr. David Sinclair (Part I)

2:01 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

longevity health

AD: On Running

1:26 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

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AD: ZipRecruiter

1:28 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

Rich Introduces Dr. David Sinclair (Part II)

2:23 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

longevity

David Spent the Morning Working Out With Laird Hamilton & Using His Sauna

5:27 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

sauna workout

How David Met Cold Therapy Guru Ray Cronise

1:24 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

Ray Cronise & Julieanna Hever's New Book, 'The Healthspan Solution'

0:29 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

Getting Your Body Out of Its Comfort Zone Fights Aging & Disease

1:22 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

longevity

Xenohormesis: Stressed Plants Contain Beneficial Polyphenolic Compounds

4:20 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

food

Exercise & Fasting Activate a Genetic Pathway That Influences Longevity

2:09 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

longevity exercise stress

Sirtuins, 'The Pianist That Plays the Genetic Piano,' Get Distracted By DNA Damage

3:26 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

genes

NAD Is Fuel for Sirtuins; Resveratrol Is the Activator

1:28 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

NAMPT, a Gene Activated By Heat, Produces NAD & Increases Sirtuin Function

2:29 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

sauna

Mix Up Your Exercise, Sauna, & Cold Therapy Routine to Maximize the Hormetic Response

1:34 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

exercise sauna sauna

Balancing Caloric Restriction & Intermittent Fasting to Maximize Hormesis

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intermittent fasting

David Sinclair's Intermittent Fasting Protocol & What Rich Has Learned from the Practice

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food

David Sinclair Is 50 and Doesn't Have a Single Gray Hair

0:17 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

Horvath's Methylation Clock Is Central to the Information Theory of Aging

4:33 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

dna genes

What's David's Biological Age According to Horvath's Methylation Clock?

0:16 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

David Is Trying to Make Horvath's Clock Biological Age Measurements More Accessible

2:49 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

longevity

Lipolysis Byproducts, Olive Oil, & Resveratrol Activate Sirtuin Enzymes

5:16 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

Consuming Resveratrol With a Fatty Solvent Increases Absorption 5-10 Fold

1:46 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

David Made a Psoriasis-Treating Molecule More Potent Than Resveratrol

0:58 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

David's Anti-Aging Work Faced Pushback from the Conventional Scientific Community

3:11 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

David Sinclair's Anti-Aging Book, 'Lifespan,' Is a Paradigm-Breaking Masterpiece

2:40 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

book

3:29 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

With His Anti-Aging Research, David Hopes to Save Billions from Being Wasted on Healthcare

3:29 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

money healthcare

David Sinclair's Mission: Convince the FDA That Aging Is a Treatable Disease

1:20 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

Your Genes Aren't Your Destiny; Lifestyle Accounts for 80% of Health in Old Age

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genes

David's Father Is 80 and Runs Around Like He's 25

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dad father

The Earlier You Invest in Longevity, the Better

0:19 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

longevity

Doctors Treat Disease Without Thinking About the Root Cause

1:50 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

If People Start Living Longer, Will Earth Become Overpopulated?

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education

Once People Start Living Longer, They'll Likely Have Kids Well Into Their Later Years

1:11 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

kids child

They'll Come a Day When a 100-Year-Old Person Isn't Considered Old

1:34 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

Easy Access to Information Makes Learning Easier Than Ever

0:44 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

As Humans Begin Living to 150+, Will They Limit Risky Behaviors?

3:45 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

risk

There's No Point in Living to 100+ If You Don't Have a Sense of Purpose

2:01 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

An Overarching Goal Helps You Push Through Life's Tough Times

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success

David's Vision for the Future: People Living to 250+ & Having Multiple Careers

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career

Living Well Into Our Hundreds Will Give People a Newfound Sense of Patience

1:28 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

50 Is the New 20 — Forget the Idea of Slowing Down in Old Age

0:54 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

As People Start Living Longer, They'll Appreciate Elderly Wisdom More

2:04 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

David Met Multiple Billionaires Because of His Successful Anti-Aging Book

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Why David Is Cautious About Recommending His Anti-Aging Supplement Routine

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supplements book supplement

To Live Longer, Eat Less Often — Stop Eating Three Meals Per Day

1:36 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

To Increase Your Lifespan: Exercise, Fast, Sleep Well, Eat Mostly Plant-Based, & Be Social

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exercise sleep foods fasting

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Why Eating a Predominantly Plant-Based Diet Is Optimal for Longevity

1:46 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

meat protein

The Carnivore Diet Accelerates Aging & Limits the Body's Defense Mechanisms

2:47 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

meat longevity

With His Current Diet & Supplement Regimen, David Never Gets Sick

0:58 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

immune system supplement supplements intermittent fasting

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diet

Sirtuins, Fueled By NAD, Control the Body's Sleep/Wake Cycle

1:26 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

sleep longevity

Why David Sinclair Supplements With NMN Instead of NR

1:43 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

supplement supplements

David Sinclair Takes Metformin to Reduce Disease Risk

1:40 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

Metformin Enhances Mitochondrial Activity Through AMPK Activation

1:31 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

Metformin Doesn't Inhibit Muscle Hypertrophy Nearly as Much as People Think

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muscle

For David Sinclair, Metformin's Benefits Outweigh Its Risks

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risk obesity longevity

David Sinclair's Mother Died from Lung Cancer

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mother

David Sinclair Is Excited About the Targeting Aging With Metformin (TAME) Trial

1:25 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

Using Genetic Reprogramming Factors, David's Lab Restored Vision in Blind Mice

6:56 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

genes

In the Future, Will Gene Therapy Heal Every Possible Ailment?

1:23 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

genes

The Future of Civilization Rests on David Sinclair's Anti-Aging Research

0:43 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

Connect With David Sinclair Online

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David & Rich Outro

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Rich Roll Outro

1:15 · Rewind Your Clock: David Sinclair, PhD Wants To 'Cure' Agingview episode

Next Time on The Rich Roll Podcast: Cyrus Khambata, Ph.D. & Robby Barbaro

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nutrition