#1349 - David Sinclair

I think, as we use this clock, we’re going to figure out that a whole bunch of stuff that we can do, and things that we can do... will not just slow aging, but reverse it. And not just by 2.5 years. Eventually, with some of the technology I talk about in my book, we think could turn the clock back by a decade or more.

These genes that extend lifespan, these sirtuin genes, are activated by being hungry—in part by raising NAD levels.

Is aging truly reversible? And that’s what this study suggests … One day we could be 80 but biologically 30.

One of the effects, in mice at least, of NMN... is improved blood flow. You get the benefits of exercise without having to exercise.

I’m a big believer in CRISPR in the sense that it will revolutionize medicine.

It’s going to be such a great world when people with 80 years of experience can continue to run companies and be teachers and educate the young people.

Antioxidants have been the biggest disappointment in the aging field… Antioxidants have, with very few exceptions, failed to extend the lifespan of any organism.

People ask me about my work: ‘Isn’t what you’re doing unnatural?’ Fuck natural. What about our world is natural anyway?

These long-lived people, they tend to live a long time no matter what they do. Often, they smoke until 90-years-old.

I don’t think we can stop climate change at this point. It’s definitely happening; you can see it all around. But will it wipe us out? No. Will it cost us trillions of dollars? Yeah.

A 50-year-old isn’t old anymore. A 50-year-old is just getting going.

Fuck keeping monkeys in a cage. That drives me so crazy. I hate it. I took a pot edible once, like a real strong one, and I went to the zoo. It was so depressing staring at the chimps. I just sat across and watched the chimp cage. I was like, ‘Oh my God, these things are in hell. They’re just in prison!'

She wanted me to do the best I could with my life. She said, ‘David, do what you can to make this world a better place. Make sure that you leave this place better than you found it,' and that’s what I’m trying to do.

One of the things people worry about if we all live longer is that we're gonna run out of food and run out of space... If you look at human history, that is not gonna happen.

Don’t give me the argument that aging is natural and therefore it’s acceptable.

I find it really interesting that we're in a new phase of society where people can learn more, in many cases, than the doctors actually know.

Metformin, although it may have an anti-aging effect, it actually decreases physical performance in athletes.

That's the problem with most medicine is that it's tailored to the average person. We have to fix that.